Phillip Kuo
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Professor of Medical Imaging
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Professor of Biomedical Engineering
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Professor of Medicine
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Professor, Cancer Biology Graduate Interdisciplinary Program
Phillip H. Kuo M.D., PhD. graduated in chemistry from Harvard and then earned an MD/PhD from the University of Virginia. Post-graduate training included residency in Internal Medicine at UCLA, fellowship in Nuclear Medicine and residency in Radiology at Yale. He has board certifications in Nuclear Medicine, Radiology, Internal Medicine, and Nuclear Cardiology. He joined the University of Arizona in 2008 and is now Professor of Medical Imaging and also faculty in Medicine and Biomedical Engineering. He currently serves as the Chief of Nuclear Medicine and Director of the Fellowship in Nuclear Radiology. Scientific interests span basic, translational and clinical research in molecular imaging.
Degrees
- M.D. Medicine
- University of Virginia, Charlottesville, Virginia, United States
- Ph.D. Molecular Physiology and Biological Physics
- University of Virginia, Charlottesville, Virginia, United States
- Molecular Mechanism of the FOF1 ATP Synthase
- M.S. Molecular Physiology and Biological Physics
- University of Virginia, Charlottesville, Virginia, United States
- B.A. Chemistry
- Harvard University, Cambridge, Massachusetts, United States
- Atmospheric carbon dioxide concentrations before 2.2 billion years ago
Work Experience
- Southern Arizona Veterans Administration Hospital (2008 - 2010)
- Yale New Haven Hospital (2005 - 2008)
Interests
Teaching
Radiology, nuclear medicine, contrast agent utilization and safety, theranostics, neurodegenerative diseases
Research
Development of contrast agents for magnetic resonance and nuclear medicine, biological effects of contrast agents, Parkinson’s disease, Alzheimer’s disease, Radiation dose reduction, Nephrogenic Systemic Fibrosis, Breast Imaging, Translational research utilizing imaging to accelerate development of therapeutics, pH imaging, PET/CT, Geology
Courses
Senior Capstone
BIOC 498 (Spring 2018)
BIOC 498 (Fall 2017)
Cnrtst Agnt Imaging+Kint
BME 522 (Spring 2022)
BME 522 (Spring 2021)
BME 522 (Spring 2020)
BME 522 (Spring 2019)
BME 524 (Spring 2018)
BME 524 (Spring 2017)
BME 524 (Spring 2016)
CBIO 522 (Spring 2020)
CBIO 524 (Spring 2017)
CBIO 524 (Spring 2016)
OPTI 522 (Spring 2021)
OPTI 522 (Spring 2020)
Licensure & Certification
- Diplomate of the American Board of Radiology, American Board of Radiology (2008)
- Diplomate of the American Board of Internal Medicine, American Board of Internal Medicine (2003)
- Diplomate of Special Certification (CAQ) in Nuclear Radiology, American Board of Radiology (2013)
- Diplomate of the American Board of Nuclear Medicine, American Board of Nuclear Medicine (2004)
- Diplomate of the Certification Board of Nuclear Cardiology, Certification Board of Nuclear Cardiology (2006)
Selected Publications
Chapters
- Zukotynski, K., Kuo, P. H., Kim, C. K., & Subramaniam, R. M. (2020). Molecular and Functional Imaging in Oncology Therapy Response. In Molecular Targeting in Oncology. Springer. doi:10.1007/978-3-030-31171-1_15
- Choudhary, G., & Kuo, P. H. (2017). Nuclear Medicine Imaging. In Nuclear Medicine Imaging. Cambridge University Press. doi:10.1017/9781316084304.010
Journals/Publications
- Warhadpande, D., Kuo, P. H., Kay, M. D., & Frazzitta, A. E. (2022). Diagnosis of Pulmonary Embolism on 99mTc-Labeled Macroaggregated Albumin Lung Imaging After Hepatic Arterial Injection for Planning of Radioembolization.. Clinical nuclear medicine, 47(3), e246-e248. doi:10.1097/rlu.0000000000004026
- Bega, D., Kuo, P. H., Chalkidou, A., Grzeda, M. T., Macmillan, T., Brand, C., Sheikh, Z. H., & Antonini, A. (2021). Clinical utility of DaTscan in patients with suspected Parkinsonian syndrome: a systematic review and meta-analysis. NPJ Parkinson's disease, 7(1), 43.
- Cox, T., Vance, C., Daley, S., Papendieck, C., McGregor, H., Kuo, P. H., & Witte, M. H. (2021). Imaging of lymphatic dysplasia in Noonan syndrome: Case studies and historical atlas. Lymphology, 54(1), 23-40.
- Kuo, P. H. (2021). Cleaning the brain through turbulent glymphatic flow: The washing machine hypothesis. Lymphology, 54(3), 133-139.
- Könik, A., Zeraatkar, N., Kalluri, K. S., Auer, B., Fromme, T. J., He, Y., May, M., Furenlid, L. R., Kuo, P. H., & King, M. A. (2021). Improved Performance of a Multipinhole SPECT for DAT Imaging by Increasing Number of Pinholes at the Expense of Increased Multiplexing. IEEE transactions on radiation and plasma medical sciences, 5(6), 817-825.
- Mustacich, D. J., Lai, L. W., Bernas, M. J., Jones, J. A., Myles, R. J., Kuo, P. H., Williams, W. H., Witte, C. L., Erickson, R. P., & Witte, M. H. (2021). Digenic Inheritance of a FOXC2 Mutation and Two PIEZO1 Mutations Underlies Congenital Lymphedema in a Multigeneration Family. The American journal of medicine.
- Neill, M., Fisher, J. M., Brand, C., Lei, H., Sherman, S. J., Chou, Y. H., & Kuo, P. H. (2021). Practical Application of DaTQUANT with Optimal Threshold for Diagnostic Accuracy of Dopamine Transporter SPECT. Tomography (Ann Arbor, Mich.), 7(4), 980-989.
- Winegar, B. A., Winegar, B. A., Morris-wiseman, L. F., Morris-wiseman, L. F., Kuo, P. H., Kuo, P. H., Kay, M. D., Kay, M. D., Caskey, J. S., & Caskey, J. S. (2021). 99mTc-Sestamibi Scintigraphy Reveals Parathyroid Adenoma Masquerading as Esophageal Diverticulum.. Clinical nuclear medicine, 46(3), e159-e161. doi:10.1097/rlu.0000000000003399
- Woodhead, G., Patel, M., Mcniel, D. B., Mcgregor, H., Kuo, P. H., Hennemeyer, C., Brunson, C., & Boros, D. (2021). Abstract No. 3 ▪ FEATURED ABSTRACT Clinical predictors of Yttrium-90 uptake in hepatocellular carcinoma: toward personalized dosimetry to maximize response to therapy. Journal of Vascular and Interventional Radiology, 32(5), S3. doi:10.1016/j.jvir.2021.03.414
- Woodhead, G., Struycken, L., Patel, M., Mcgregor, H., Kuo, P. H., & Hennemeyer, C. (2021). Abstract No. 34 Planar scintigraphy overestimates hepatopulmonary shunt fractions compared with quantitative SPECT/CT. Journal of Vascular and Interventional Radiology, 32(5), S16. doi:10.1016/j.jvir.2021.03.450
- Zeraatkar, N., Kalluri, K. S., Auer, B., May, M., Richards, R. G., Furenlid, L. R., Kuo, P. H., & King, M. A. (2021). Cerebral SPECT imaging with different acquisition schemes using varying levels of multiplexing versus sensitivity in an adaptive multi-pinhole brain-dedicated scanner. Biomedical physics & engineering express, 7(6).
- Zukotynski, K., Black, S. E., Kuo, P. H., Bhan, A., Adamo, S., Scott, C. J., Lam, B., Masellis, M., Kumar, S., Fischer, C. E., Tartaglia, M. C., Lang, A. E., Tang-Wai, D. F., Freedman, M., Vasdev, N., & Gaudet, V. (2021). Exploratory Assessment of K-means Clustering to Classify 18F-Flutemetamol Brain PET as Positive or Negative. Clinical nuclear medicine, 46(8), 616-620.
- Auer, B., Zeraatkar, N., Goding, J. C., Konik, A., Fromme, T. J., Kalluri, K., Furenlid, L. R., Kuo, P. H., & King, M. A. (2020). Inclusion of quasi-vertex views in a brain-dedicated multi-pinhole SPECT system for improved imaging performance. Physics in medicine and biology.
- Chen, N., Chou, Y., Stuehm, C., Zhang, X., & Kuo, P. H. (2020). Functional Magnetic Resonance Imaging Reveals Taiji’s Real-time Effects on Neuronal Networks of the Brain. The Journal of Chinese Health Practices, 1(1).
- Chen, N., Chou, Y., Stuehm, C., Zhang, X., & Kuo, P. H. (2020). Functional Magnetic Resonance Imaging Reveals Taiji’s Real-time Effects on Neuronal Networks of the Brain. The Journal of the International Society of Chinese Health Practices, 1.
Proceedings Publications
- Auer, B., Zeraatkar, N., De Beenhouwer, J., Kalluri, K., Furenlid, L., Kuo, P. H., & King, M. (2019, June). Investigation of a Monte Carlo simulation and an analytic-based approach for modeling the system response for clinical I-123 brain SPECT imaging. In 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Fully3D 2019, 11072.
- Kalluri, K., Zeraatkar, N., Auer, B., Kuo, P. H., Furenlid, L., & King, M. (2019, June). Preliminary investigation of AdaptiSPECT-C designs with square or square and hexagonal detectors employing direct and oblique apertures. In 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Fully3D 2019, 11072.
- Witte, M. H., Mustacich, D., Moedano, L., Behan, S., Bernas, M. J., Klewer, S. E., Barber, B. J., Kuo, P. H., & Kylathu, R. (2019, September). Whole Body Lymphangioscintigraphy and SPECT-CT in Infants and Children with Lymphatic Congestion after Surgical Repair of Complex Congenital Heart Disease. In 27th World Congress of Lymphology Abstract Booklet.
- Zeraatkar, N., Auer, B., Kalluri, K., Furenlid, L., Kuo, P. H., & King, M. (2019, June). GPU-accelerated generic analytic simulation and image reconstruction platform for multi-pinhole SPECT systems. In 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Fully3D 2019, 11072.
- Zukotvnski, K., Thiel, A., Tardif, J., Soucy, J., Sossi, V., Smith, E. E., Scott, C. J., Sahlas, J. D., Prato, F. S., Noseworthy, M. D., Laforce, R., Kuo, P. H., Hsiung, R., Goubran, M., Gaudet, V. C., Frayne, R., Chertkow, H., Borrie, M., Bocti, C., , Black, S. E., et al. (2019). Non-Binary Approaches for Classification of Amyloid Brain PET. In 2019 IEEE 49th International Symposium on Multiple-Valued Logic (ISMVL), 206-211.
Poster Presentations
- Granados, J., Pagel, M., Yi, S. K., Kuo, P. H., Randtke, E. A., Granados, J., Pagel, M., Yi, S. K., Kuo, P. H., & Randtke, E. A. (2017, September 13-16). Comparisons of Non-linear Bloch Fitting and MRI Fingerprinting for acidoCEST MRI. World Molecular Imaging Congress (WMIC). Philadelphia, PA: World Molecular Imaging Society (WMIS).
- Kuo, P. H. (2017, fall). Lymphangioscintigraphy Patterns of Lymphedema in Gynecologic Cancer and Related Disorders. 26th International Congress of Lymphology.. Barcelona, Spain: 26th International Congress of Lymphology.
- Kuo, P. H. (2017, fall). Whole Body Lymphangioscintigraphy and SPECT-CT in Infants and Children with Chylous Reflux after Surgical Correction of Congenital Heart Disease. Whole Body Lymphangioscintigraphy and SPECT-CT in Infants and Children with Chylous Reflux after Surgical Correction of Congenital Heart Disease. Barcelona, Spain.
- Kuo, P. H., & Witte, M. H. (2015, Sep). Whole Body Lymphangioscintigraphy and SPECT-CT in Neonates, Infants and Small Children with Chylous Reflux Syndromes. 25th World Congress of Lymphology. San Francisco, CA.
- Kuo, P. H., Covington, M., & McMillan, N. (2015, may). Trends for Reimbursement of Dopamine Transporter Imaging from Past to Present. American College of Radiology Annual Conference. Washington DC: American College of Radiology.
- Kuo, P. H., Gonzalez, V. J., Grow, J., Choudhary, G., & Livingston, R. B. (2015, Dec). Incidence of Internal Mammary Node, Sternum, and Manubrium Failure as Detected by FDG-18 PET/CT. San Antonio Breast Cancer Symposium. San Antonio, TX.
- Kuo, P. H., John, S., & Reininger, C. (2015, Jan). Early Experience with the High Contrast Novel B-Amyloid Tracer 18F NAV4694 Correlation of Visual Interpretation with Clinical and Quantitative Parameters. Human Amyloid Imaging Conference. Miami, FL.
- Kuo, P. H., Kubal, W. S., & Chaudhary, G. (2015, Sep). Nuclear Imaging for Determination of Brain Death: Primer for the Emergency Radiologist. American Society of Emergency Radiology Annual Meeting. Miami, FL: American Society of Emergency Radiology.
- Kuo, P. H., Thai, J., & Abidov, A. (2015, May). Nuclear Myocardial Perfusion Imaging Versus Stress Echocardiography in the Pre-operative Evaluation of Patients for Kidney Transplantation. American College of Radiology Annual Conference. Washington DC: American College of Radiology.
- Kuo, P. H., Zubal, G., Alexander, G., Krafft, W., Fitzhugh, M., & Bharadwaj, P. (2015, October). Rapid, fully automated method for quantitative analysis of PET amyloid scans in Alzheimer’s disease. Annual Meeting Society for Neuroscience. Chicago, IL: Society for Neuroscience.
Presentations
- Kuo, P. H. (2019, December). Brain FDG and Amyloid PET/DAT Scans. Radiological Society of North America (RSNA) Annual Meeting. Chicago, IL: RSNA.
- Kuo, P. H. (2019, February). Challenging PET/CT Cases. American College of Radiology PET/CT Course. Reston, VA.
- Kuo, P. H. (2019, June). Challenging PET/CT Cases. American College of Radiology PET/CT Course. Reston, VA.
- Kuo, P. H. (2019, June). Nuclear Medicine Review of CT/MRI Correlation. Society of Nuclear Medicine and Molecular Imaging Annual Meeting. Anaheim, CA.
- Kuo, P. H. (2019, June). Pearls and Pitfalls of DaTQUANT. Society of Nuclear Medicine and Molecular Imaging Annual Meeting. Anaheim, CA.
- Kuo, P. H. (2019, June). Pearls for Interpreting DaTscan. Society of Nuclear Medicine and Molecular Imaging Annual Meeting. Anaheim, CA.
- Kuo, P. H. (2019, June). Review of Molecular Neuroimaging for Neurodegenerative Disorders. Society of Nuclear Medicine and Molecular Imaging Annual Meeting. Anaheim, CA.
- Kuo, P. H. (2019, March). Brain Scintigraphy. American College of Radiology Nuclear Medicine Course. Reston, VA.
- Kuo, P. H. (2019, March). Nuclear Cardiology. American College of Radiology Nuclear Medicine Course. Reston, VA.
- Kuo, P. H. (2019, March). Radium-223 Therapy. American College of Radiology Nuclear Medicine Course. Reston, VA.
- Kuo, P. H. (2019, March). Renal Scintigraphy. American College of Radiology Nuclear Medicine Course.
- Kuo, P. H. (2019, March). VQ scans and Artifacts. American College of Radiology Nuclear Medicine Course.
- Kuo, P. H. (2019, May). PET/CT of GU Malignancy- Prostate Cancer. American Roentgen Ray Society Annual Meeting. Honolulu, HI.
- Kuo, P. H. (2019, May). Radiology Review of Nuclear Medicine: Abdominal and Musculoskeletal Scintigraphy. American Roentgen Ray Society Annual Meeting. Honolulu, HI.
- Kuo, P. H. (2019, November). Connection between the Lymphatics/Glymphatics of the Central Nervous System and Tai Chi. Invited lecturer Beijing University, Beijing, China. Beijing, China.
Others
- Kuo, P. H., & Fischachs, J. (2019, July). Realization of a 20-year-old Dream: the International Society of Chinese Health Practices. University of Arizona News.
- Harb, W., Kuo, P., Sparks, R., Binh Nguyen, ., & Symanowski, J. (2014, MAY). Biodistribution and safety of the folate receptor imaging agent Tc-99m-etarfolatide: Phase 1 trial in healthy volunteers. JOURNAL OF NUCLEAR MEDICINE.
- Nawas, M. T., Kubal, W. S., & Kuo, P. H. (2014, SEP). Decreased Cerebellar Activity on FDG PET/CT Secondary to Diffuse Idiopathic Cerebellar Calcification. CLINICAL NUCLEAR MEDICINE.
- Avery, R., & Kuo, P. H. (2013, SEP). F-18 Sodium Fluoride PET/CT Detects Osseous Metastases From Breast Cancer Missed on FDG PET/CT With Marrow Rebound. CLINICAL NUCLEAR MEDICINE.
- Kuo, P., Van Heertum, R., Nguyen, B., Bateman, D., Symanowski, J., & Naumann, R. (2012, MAY). A pilot study assessing interreader variability in the evaluation of folate receptor status of ovarian cancer patients using Tc-99m-etarfolatide. JOURNAL OF NUCLEAR MEDICINE.
- Hur, S., Howell, B., Krupinski, E., & Kuo, P. (2007, MAY). Comparison of three protocols for gallbladder ejection fraction by hepatobiliary scintigraphy. JOURNAL OF NUCLEAR MEDICINE.
Awards
- Certificate of Merit award for education exhibit “Signs and Artifacts in Amyloid PET” at 104th Scientific Assembly and Annual Meeting of the Radiological Society of North America
- RSNA, Winter 2018
- Best Clinical Paper Award at the World Molecular Imaging Congress 2018
- World Molecular Imaging Congress, Summer I 2018
- Grand Saguaro Award for Outstanding Teaching of Medical Students
- UA, Summer I 2018
- Sixth Annual Dr. Tapan K. Chaudhuri Lecturer at Eastern Virginia Medical School
- EVMS, Spring 2018
- Plenary speaker for 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference
- IEEE, Winter 2017
- Castle Connolly “Top Doctors” in Diagnostic Radiology
- Castle Connolly, Spring 2016
- Grand Saguaro Award for Teaching of Medical Students
- University of Arizona Department of Medical Imaging, Spring 2014